Ferrous ascorbate it is a synthetic molecule of iron with ascorbate, is an emerging oral iron preparation.

There are two types of oral iron supplements which contain either the ferrous or ferric form of iron. Absorption of ferrous form of iron is more than ferric form.

Ferrous ascorbate because of its ascorbate content and antioxidant property proves to be a promising molecule as an iron supplement. If iron is in the conventional ferrous salt form it undergoes oxidation by food constitutes, oxidation by the alkaline environment so there are reduced absorption and more GI side effects. Ascorbic acid helps in incredible iron absorption and also inhibits the effects of phytates, phosphates and oxalates on iron absorption. It also has less GI side effects. (16) Ferrous ascorbate contains 12-15% of iron which provides a large dose of ascorbic acid per mg of iron ingested. (17)

Ferrous ascorbate offers significant clinical advantages in terms of high bioavailability, efficacy coupled with excellent safety and tolerability that makes it an iron preparation of the first choice in the treatment of IDA. (18)

Adult population

Many studies have demonstrated the efficacy of ferrous ascorbate in the treatment of IDA. Absorption of ferrous ascorbate is up to 67% in patients with Iron Deficiency. (18) Also, Ferrous ascorbate showed a significantly higher rise in Hb as compared to ferrous Sulphate. (19)

Pediatric population

A ferrous ascorbate is an effective option of iron salt in the management of IDA in children as it has good acceptability and negligible side effects. (17)

Dosage and Administration

One tablet to be taken once daily, or as directed by the physician.

Contraindications

  • Hypersensitivity to iron or any component of the formulation Iron
  • Overload or disturbances in iron utilization
  • Anemia not caused by iron deficiency

Overdose

Management includes feeding eggs and milk (to form iron-protein complexes), gastric lavage with 1% sodium bicarbonate solution (to convert the iron to a less soluble form), deferoxamine mesylate; measures to combat shock, dehydration, blood loss and respiratory failure may be necessary. (20)

Adult population

Many studies have demonstrated the efficacy of ferrous ascorbate in the treatment of IDA. Absorption of ferrous ascorbate is up to 67% in patients with Iron Deficiency. (18) Also, Ferrous ascorbate showed a significantly higher rise in Hb as compared to ferrous Sulphate. (19)